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14.12.2010


Cirsium oligophyllum extract enhances slimming effect of caffeine

Cirsium oligophyllum extract enhances slimming effect of caffeine
An alcohol/water based extract of the thistle Cirsium oligophyllum enhances the slimming effect of ordinary old caffeine, according to researchers at the Japanese Kao Corporation. Rats given the extract in their drinking water lost at least 26 percent of their subcutaneous fat in just 32 days.

Cirsium oligophyllum is already on the market. Unclear amounts of an extract of the leaves of this Japanese thistle are contained in OxyElitePro, a slimming supplement from USP Labs. The most important component in this product seems to be methylhexanamine.

We've not been able to find much about Cirsium oligophyllum in the literature, and the Japanese study leaves us none the wiser either. The research describes it as "a commercially available crude drug with lipolysis-promoting activity" and says nothing more about it.

The researchers gave rats water containing 3 or 10 percent alcohol/water-extract twice a day. The stronger concentration certain led to weight loss. The extract didn't reduce food intake, but nonetheless subcutaneous fat reduced by 26.2 percent.


Cirsium oligophyllum extract enhances slimming effect of caffeine

Cirsium oligophyllum extract enhances slimming effect of caffeine


When the researchers did tests with subcutaneous fat cells, they saw that the beta-blocker propranolol completely blocks the anti-obesity effect of Cirsium oligophyllum. The figure below shows the cells' emission of glycerol, a marker of the amount of fatty acids the fat cells release into the blood.

Propranolol sabotages the beta-adrenergic receptors, thus inhibiting the effect of adrenalin. When the researchers added caffeine to the cells, the anti-obesity effect of Cirsium oligophyllum increased.


Cirsium oligophyllum extract enhances slimming effect of caffeine

Cirsium oligophyllum extract enhances slimming effect of caffeine


The researchers also rubbed a solution into the rats' skin, and observed that they lost subcutaneous fat in this way too. "Further studies are necessary to confirm the action mechanism of this material, involving alteration of the energy balance, and to evaluate its possible application to health promotion and esthetics", they write.

Source:
Int J Biol Sci. 2009; 5(4): 311-8.

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