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19.05.2018


12,13-Di-HOME: a new fat loss agent? Or a new undetectable endurance drug?

12,13-Di-HOME: a new fat loss agent? Or a new undetectable endurance drug?
Not so long ago, researchers from Ohio State University and Harvard University published a study in Cell Metabolism that made the science of fat burning by physical activity a bit more complicated - and more interesting. And that study may have revealed the existence of a new ergogenic compound. It could be that the linoleic acid metabolite 2,13-diHOME is an effective fat loss agent - and perhaps even an undetectable endurance drug.

Study
The researchers came of track of 12,13-diHOME when they scanned the blood of a diverse group of human subjects for fatty acid metabolites that had been raised or lowered after 40 minutes of cycling.

The researchers studied about ninety metabolites, and the metabolite whose concentration during and after the effort increased the most was 12.13-diHOME [left below].


12,13-Di-HOME: a new fat loss agent? Or a new undetectable endurance drug?



Fitter & slimmer
The more 12,13-diHOME the researchers found in the blood of the study participants, the fitter they were [left below] and the less fat mass they carried with them [right below].


12,13-Di-HOME: a new fat loss agent? Or a new undetectable endurance drug?



When the researchers did experiments with mice, they discovered that the animals produced almost no 12,13-diHOME through movement when they had no more brown adipose tissue. Thus, 12,13-diHOME is produced by brown fat cells.


12,13-Di-HOME: a new fat loss agent? Or a new undetectable endurance drug?



Brown fat cells not only store fat, but also burn it and convert it into heat. The discovery of 12,13-diHOME has made brown fat tissue even more interesting than it already was.

Fat oxidation by muscle cells
In experiments with fat cells and muscle cells in test tubes, the researchers discovered that 12,13-diHOME stimulated the uptake and oxidation of fatty acids by muscle cells, but had no influence on fat absorption and fat burning of fat cells.


12,13-Di-HOME: a new fat loss agent? Or a new undetectable endurance drug?


12,13-Di-HOME: a new fat loss agent? Or a new undetectable endurance drug?



12,13-DiHOME had no effect on glucose metabolism.

When the researchers injected mice with 12,13-diHOME, they saw that the metabolite - the researchers prefer the term lipokine - reduced the respiratory exchange ratio. This means that the animals burned more fat but less glucose.

Also striking is the dose that the researchers used. If the mice had been 80 kilograms, they would have received an injection of 8 micrograms of 12,13-diHOME.

That's not much.


12,13-Di-HOME: a new fat loss agent? Or a new undetectable endurance drug?



Wild speculations
What would happen if cyclists or runners take an injection with 12,13-diHOME before a race? We do not know that for sure, but we, the ignorant compilers of this free web magazine, suspect that their endurance would increases. Especially in combination with substances that promote lipolysis. Like, ehm, good old caffeine.

We will keep you informed.

Source:
Cell Metab. 2018 May 1;27(5):1111-1120.e3.

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