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19.09.2015


Xanthigen increases energy expenditure by 400 kcal per day

Losing weight might be easier if you take the slimming supplement Xanthigen. It contains a combination of fucoxanthin, a substance found in edible algae, and punicic acid, a fatty acid found in pomegranate, which can increase your calorie expenditure by up to 400 kilocalories a day. Do you believe it or not?

Xanthigen
Xanthigen increases energy expenditure by 400 kcal per day
Xanthigen is a slimming substance produced by PLT Health Solutions. [plthealth.com] The manufacturer claims that people who use the product burn 400 kcal more every day. Websites selling Xanthigen point to proof in the form of a human study published in 2010 by researchers at the Russian Academy of Natural Science in Moscow in Diabetes, Obesity and Metabolism.

Xanthigen consists of a combination of fucoxanthin and punicic acid, a combination the researchers have patented. [US Patent 8,367,072]

Fucoxanthin
Fucoxanthin [structural formula shown below] is a carotenoid found in brown algae. Animal studies have shown that it causes energy expenditure to rise because it activates UCPs. [Biochem Biophys Res Commun. 2005 Jul 1;332(2):392-7.] As a result of that, cell metabolism increases and nutrients are converted less economically into energy.


Xanthigen increases energy expenditure by 400 kcal per day



Punicic acid
Punicic acid [structural formula shown below] is a 9-cis, 11-trans CLA found in pomegranate seed oil. Pomegranate Seed Oil consists for 70-80 percent of punicic acid. Animal studies have shown that punicic acid supplementation reduces the size of fat reserves. [Lipids Health Dis. 2004 Nov 9;3:24.]


Xanthigen increases energy expenditure by 400 kcal per day



Study
The Russians tested different doses of fucoxanthin and pomegranate seed oil on obese women. Fucoxanthin alone in daily doses of 8 mg had a strong effect on calorie expenditure at rest, the researchers discovered. Women who took this dose burned 458 kcal more than normal each day.


Xanthigen increases energy expenditure by 400 kcal per day



Pomegranate seed oil on its own had no noticeable effect on energy expenditure, but did enhance the effect of lower doses of fucoxanthin on the body's metabolism.


Xanthigen increases energy expenditure by 400 kcal per day



The researchers then gave 72 obese women a placebo or 600 mg Xanthigen (300 mg pomegranate seed oil and 2.4 mg fucoxanthin in the form of 300 mg seaweed extract, every day for 16 weeks. The women lost almost 7 kg bodyweight. The women in both groups had been given a diet containing 1800 kcal daily.


Xanthigen increases energy expenditure by 400 kcal per day



From week 6 [where the arrow is in the graph] of the experiment the women who took Xanthigen started to lose weight significantly faster than the women in the placebo group.


Xanthigen increases energy expenditure by 400 kcal per day



Xanthigen did not spare the subjects' lean body mass. The women who took Xanthigen also lost a couple of kilograms of lean body mass [i.e. muscle mass]. This did not happen in the placebo group.

Conclusion
"This trial is the first clinical evidence reporting the anti-obesity effect of Xanthigen, with special relevance to obese patients", the Russians wrote. "Although the effect of fucoxanthin and Xanthigen on the expression and induction of the UCP protein was not the objective of this clinical trial, resting energy expenditure increases may be related to the induction of UCP proteins by fucoxanthin as previously demonstrated in rodents."

Source:
Diabetes Obes Metab. 2010 Jan;12(1):72-81.