Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
Trial: magnesium effective antidepressant
The participants had low levels of magnesium in their blood. Healthy people have somewhere between 1.7 and 2.3 mg magnesium per decilitre blood. When the study started the participants in both groups had 1.8 mg magnesium per decilitre. That's not unusual: most people in modern societies have low magnesium levels.
Adults should consume about 300-400 mg magnesium daily. But because we are eating more and more industrially processed foods that do not contain much magnesium, most people don't consume anything like this amount.
The researchers used the Beck Depression Inventory-II questionnaire to determine the severity of depression and observed that the severity decreased in both groups. However, the decrease in the magnesium group (16 points) was significantly bigger than in the placebo group (10 points).
"Cyclic adenosine monophosphate response element-binding protein is a protein that regulates the activity of the genes affecting the function of human brain, especially the genes involved in the production of dopamine. BDNF is a neurotropic factor widely expressed in the central nervous system, playing an important role in the evolution of brain, survival, and maintenance of neurons."
"Furthermore, BDNF also has a role in inhibition of NMDA channels."
"In some studies, increased expression of the BDNF gene has been observed after treatment with electric shock and some antidepressants. Therefore, magnesium can be effective in improving depression."