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09.06.2018

Terbutaline tabs for a month: gain 2 kilos of muscle, lose 1 kilo of fat

Researchers from the University of Copenhagen discovered that the asthma medicine terbutaline, administered by an inhaler, increases muscle mass by a kilo. That's what we wrote 2 days ago. In 2015, the same researchers published a study in which they had volunteers take a large amount of terbutaline tablets. The body recompositioning effects were even more impressive.

Study
The researchers experimented with 18 active males in their twenties. They did cycling, running or fitness, and trained for 4-8 hours a week. During the experiment they continued to exercise as they were used to.

The researchers divided the men into 2 groups. For 4 weeks one group received a placebo, and the other terbutaline.

The maximum medical dose for adults is 15 milligrams of terbutaline per day, divided over three intakes. The researchers gave their test subjects 2-3 fold of that dose: for every 30 kg of body weight the subjects took 5 milligrams of terbutaline sulphate every day, twice a day. The researchers used Bricanyl Retard from AstraZeneca.

Results
The isometric strength [Maximal voluntary contraction] that the subjects could develop when performing a leg extension remained constant in the placebo group, but increased by 97 Newton in the terbutaline group.

During a cylcing sprint of 30 seconds, the subjects in the terbutaline group [TER] could develop more power after 4 weeks. That means they got faster. This did not happen in the placebo group [PLA].

The lean body mass [say: the muscle mass] in the terbutaline group increased by two kilos compared to the placebo group. At the same time, the fat mass in the terbutaline group decreased by 1 kilo compared to the placebo group.

In muscle cells, taken form the men's legs, the researchers found an increase in the muscle proteins myosin heavy chain I and myosin heavy chain II in the terbutaline group.

In the muscle cells, terbutaline had no effect on the production of the muscle growth-inhibiting protein myostatin. However, the drug did increase the production of follistatin. Follistatin inactivates myostatin.

Side effects
The dose of terbutaline used was not without side effects. In the first week of the experiment, some subjects experienced tremors, palpitations and restlessness. After the first week, the side effects disappeared.

Conclusion
"Given the performance-enhancing nature of acute and chronic beta-2-adrenergic stimulation on muscle mass, muscle force, and power output during maximal exercise, it seems logical that systemic use of beta-2-agonists should remain on the list of prohibited substances in competitive sports", write the researchers.

Source:
J Appl Physiol (1985). 2015 Sep 1;119(5):475-86.

More:
Taking eight puffs of terbutaline every day results in a kilo of extra muscle mass 4 weeks later 07.06.2018

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