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Daily supplementation with 250 mg oleoylethanolamide causes fat loss

Daily supplementation with a few hundred milligrams oleoylethanolamide may make a fat loss diet easier and less unpleasant. Iranian nutritional scientists from Iran conclude this from a human trial, that had been published in Appetite. Although the Iranians' study subjects did not have to change their way of life, they spontaneously lost a few pounds of fat. The supplement made them eat less.


Oleoylethanolamide [structural formula below] is found in microgram quantities in oats, cocoa and nuts, but the small intestine manufactures the stuff in significantly larger quantities. The more monounsaturated fatty acids from, for example, olive oil, avocados and nuts you consume, the more oleoylethanolamide circulates in your body. [Food Funct. 2015 Jan;6(1):204-10.]

Daily supplementation with 250 mg oleoylethanolamide causes fat loss

Oleoylethanolamide is an endocannabinoid: an endogeneous substance that interacts with endocannabinoid receptors. According to an old theory, formulated in the nineties, oleoylethanolamide prevents another endocannabinoid, arachidonylethanolamine, from interacting with the cannabinoid-type-1 receptor [CB1]. Because arachidonylethanolamine stimulates appetite through interaction with CB1, oleoylethanolamide may reduce appetite.

Theory is good, but proof is better. Is oleoylethanolamide an effective fat loss agent in the real world? To find out, food scientists from the University of Tabriz did an experiment with 57 obese people aged 18-59 years. During 8 weeks, one half of them received 2 capsules of 125 milligram oleoylethanolamide daily, and the other half a placebo.

The researchers used oleoylethanolamide which they had synthesized themselves. The dose they used was not extreme. For example, the oleoylethanolamide supplement from RiduZone contains 200 milligrams of oleoylethanolamide per capsule.

Daily supplementation with 250 mg oleoylethanolamide causes fat loss

The fat mass of the subjects who used oleoylethanolamide decreased by 1.3 kg; the fat mass of the subjects in the placebo group increased by just over half a kilo.

Daily supplementation with 250 mg oleoylethanolamide causes fat loss

It was mainly the abdominal fat that subsided in the oleoylethanolamide group, the figure below suggests.

Daily supplementation with 250 mg oleoylethanolamide causes fat loss

Supplementation with oleoylethanolamide reduced feelings of hunger, the test subjects in the oleoylethanolamide arm reported. They not only had less appetite for food than the subjects in the placebo group, but also had a stronger feeling of satiety and fullnes after their meals.

When the researchers analyzed blood cells from their subjects, taken before and after the administration of oleoylethanolamide, they saw that the supplement had switched on the PPAR-alpha gene. They suspect that oleoylethanolamide reduces appetite by inducing this gene.

Daily supplementation with 250 mg oleoylethanolamide causes fat loss

"The main finding of this study is that supplementation with 2 x 125-mg oleoylethanolamide capsules for 8 weeks enhanced the expression of the PPAR-alpha gene, improved anthropometric measurements (weight, BMI, waist circumference, and fat mass) and appetite sensations (hunger, desire to eat foods, and cravings for sweets decreased, and fullness increased)", write the Iranians.

"Considering the many beneficial effects of oleoylethanolamide in various metabolic pathways, its use as a complementary approach to weight loss could be effective in suppressing appetite and controlling weight in obese people; however, further studies are needed to confirm the current results."

Appetite. 2018 May 19. pii: S0195-6663(18)30155-7.

N-oleyl-phosphatidyl-ethanolamine & EGCG combo makes weight-loss diet easier 03.02.2013

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