Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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14.04.2020 |
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Polyacetylenes for diabetics (and bodybuilders)
Polyacetylenes not only inhibit cancer, but may also mimic and enhance the effect of insulin. This is suggested by a Danish in vitro study published in Food & Function in 2015. The research suggests that falcarinol and falcarindiol stimulate the uptake of glucose by muscle cells, and that falcarinol can also stop the growth of fat cells.
Muscle cells
Fat cells
Rosiglitazone interacts with PPAR-gamma. You can describe PPARs as receptors for fat, which tell cells that fatty acids are nearby and stimulate cells to absorb fatty acids such as glucose.
Computer simulations enabled the Danes to demonstrate that falcarinol and falcarindiol, like rosiglitazone, interact with PPAR.
Conclusion
"[However], the slightly different effects of the two polyacetylenes that both enhance glucose uptake suggest that they are of interest in relation to prevention and/or treatment of type-2 diabetes and could serve as interesting scaffolds for novel PPAR-gamma partial agonist with insulin sensitizing properties."
Pretty nice stuff, those polyacetylenes. More coming soon.
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