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23.09.2013


Piceatannol inhibits spread of prostate cancer

The resveratrol metabolite piceatannol inhibits prostate cancer, researchers at Hallym University in South Korea discovered. Piceatannol inhibits the spread of prostate cancer cells through the body. One of the ways in which it does this is by sabotaging the inflammatory protein interleukine-6.
The resveratrol metabolite piceatannol inhibits prostate cancer, researchers at Hallym University in South Korea discovered. Piceatannol inhibits the spread of prostate cancer cells through the body. One of the ways in which it does this is by sabotaging the inflammatory protein interleukine-6.

When researchers discover a new substance that enhances athletic performance, it's usually just a matter of time before other researchers declare that the same substance causes cancer. That's not so surprising, as the processes involved in cell growth resemble to some extent the processes involved in the growth of cancer cells.

That's why we're interested in piceatannol. Piceatannol is an NO booster, it has an anticatabolic effect, stimulates the uptake of nutrients from the bloodstream by muscle cells and not by fat cells, and to top it off it probably also stimulates the synthesis of EPO.

So you'd imagine that piceatannol is almost bound to have a carcinogenic effect too. But according to Korean researchers who are studying prostate cancer, this is not the case. In 2009 they published the results of an in-vitro study in which piceatannol induced androgen-insensitive DU 145 prostate cancer cells to commit suicide. [J Med Food. 2009 Oct;12(5):943-51.] Researchers have also observed these cancer-inhibiting effects of piceatannol in liver cancer cells, breast cancer cells and intestinal cancer cells. [Biomed Res Int. 2013;2013:514349.]

The Koreans tested the cancer-inhibiting effect of piceatannol by doing an experiment in which they injected mice's tails with labelled MLL prostate cancer cells. These cells produce a fluorescent protein, which enabled the researchers to follow the cancer cells as they spread. The mice were given 0, 10 or 20 mg piceatannol per kg bodyweight for nine consecutive days. You can calculate the human equivalent of these doses here.

The more piceatannol the mice were given, the more slowly the cancer cells spread through the body.


The resveratrol metabolite piceatannol inhibits prostate cancer, researchers at Hallym University in South Korea discovered. Piceatannol inhibits the spread of prostate cancer cells through the body. One of the ways in which it does this is by sabotaging the inflammatory protein interleukine-6.


The resveratrol metabolite piceatannol inhibits prostate cancer, researchers at Hallym University in South Korea discovered. Piceatannol inhibits the spread of prostate cancer cells through the body. One of the ways in which it does this is by sabotaging the inflammatory protein interleukine-6.


The resveratrol metabolite piceatannol inhibits prostate cancer, researchers at Hallym University in South Korea discovered. Piceatannol inhibits the spread of prostate cancer cells through the body. One of the ways in which it does this is by sabotaging the inflammatory protein interleukine-6.


The resveratrol metabolite piceatannol inhibits prostate cancer, researchers at Hallym University in South Korea discovered. Piceatannol inhibits the spread of prostate cancer cells through the body. One of the ways in which it does this is by sabotaging the inflammatory protein interleukine-6.


In tests with DU 145 prostate cancer cells the researchers observed that piceatannol inhibited the synthesis of interleukine-6, VEGF and urokinase-type plasminogen activator [uPA]. Interleukine-6 deactivates suicide mechanisms in cancer cells, VEGF forces the body to create new blood vessels for cancer cells, uPA plays a role in the spread of cancer cells through the body.

Piceatannol reduced not only the synthesis of interleukine-6, but also encouraged the prostate cancer cells not to react to it. When the researchers exposed their prostate cancer cells to interleukine-6, they synthesised more VEGF and the growth promoting uPA. Piceatannol inhibited this response.


The resveratrol metabolite piceatannol inhibits prostate cancer, researchers at Hallym University in South Korea discovered. Piceatannol inhibits the spread of prostate cancer cells through the body. One of the ways in which it does this is by sabotaging the inflammatory protein interleukine-6.


"Because the incidence of prostate cancer is relatively high in elderly men and hormone-refractory prostate cancer does not respond well to the currently available chemotherapeutic agents, the piceatannol-induced inhibition of metastatic potential in androgen-independent prostate cancer cells may generate significant preventive benefits", the Koreans conclude.

Source:
J Nutr Biochem. 2012 Mar;23(3):228-38.

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Piceatannol makes L-arginine a more effective nitrogen monoxide donor 12.09.2013
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