Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
How harmful is ecdysterone?
Restricting themselves to cardiovascular disease, the New Orleans researchers tried to answer that question. For this, they used the data from almost a half-million Britons, who had been collected in the Biobank study. The data collection began in the 2006-2010 period, and the researchers were able to follow the study participants until 2016.
At the same time, the urine of the test animals had started to contain more albumin proteins through the administration of ecdysterone. Together with the enlargement of the kidneys, this indicates kidney damage.
The mineralocorticoid receptor is intended for hormones like aldosterone. Aldosterone allows the body to retain more fluid and increases blood pressure. A high blood pressure can in turn lead to kidney damage.
The researchers then exposed kidney cells to ecdysterone in test tubes. They saw that ecdysterone activated the mineralocorticoid receptor, and let them travel from the cytosol to the cell nucleus. This did not happen if the researchers also put spironolactone in the test tubes. Spironolactone is a mineralocorticoid receptor blocker.
"This harmful effect is likely accounted for by a mineralocorticoid-like activity of ecdysone that is able to activate the mineralocorticoid receptor in glomerular cells and trigger cytopathic changes, and can be abolished by the mineralocorticoid receptor blocker spironolactone."
"Our findings suggest that the use of ecdysone, a popular anabolic and adaptogenic agent, may be problematic, at least for kidney health and thus warrants extra precautions."