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Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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12.09.2023 |
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Citrus flavonoid hesperidin stops muscle breakdown due to aging
Hesperidin, a flavonoid found in significant amounts in oranges, inhibits muscle breakdown and stimulates muscle building. This is suggested by a Korean animal study conducted with older lab mice.
Study
Another group of older mice received no active substances.
When the 8 weeks were over, the researchers studied the muscle tissue of the test animals. They compared the tissue with that of young mice.
Results
Hesperidin reduced the activity of inflammatory proteins such as TNF-alpha and interleukin-1-beta and catabolic signaling molecules such as MURF1 in the old mice. This is indicated by the figures above.
At the same time, hesperidin supplementation increased the activity of anabolic signaling molecules, such as p-mTOR, p-AKT, myogenin and myo-D. The figures below refer to the quadriceps.
Conclusion
Hesperidin is found in oranges, especially blood oranges. A 200 milliliter glass of fresh blood orange juice contains approximately 80 milligrams of hesperidin. [J Agric Food Chem. 2000 Nov;48(11):5501-6.] An equal glass of juice from regular oranges contains 50 milligrams. [J Agric Food Chem. 1994 Oct;42:(10)2183-90.] If people respond to hesperidin in the same way as mice, then you should get active amounts of hesperidin through oranges.
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