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Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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28.02.2015 |
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Sepsis even more deadly for steroids users
Blood poisoning – sepsis or septicaemia in medical language – is even more dangerous for steroids users than for ordinary mortals who do not use anabolic pharmaceuticals. Researchers at Changhua Christian Hospital in Taiwan published an article on this in Kaohsiung Journal of Medical Sciences.
Sepsis
In theory, anabolic hormones raise the chance of septic shock occurring. IGF-1 activates the molecular switches extracellular-signal-regulated kinases 1 and 2 and nuclear factor kappa B in the body's cells. These molecular switches are involved in anabolic processes, but also in inflammatory reactions, which cells use to protect themselves against pathogens. In extreme cases of exposure to these substances, the immune reactions that occur cause septic shock.
So if a pathogenic bacteria ends up in the bloodstream of a steroids user, you would expect his body to react more severely than that of a non-user.
The Taiwanese tested this theory by giving male mice daily injections of the anabolic steroid nandrolone phenylproprionate [structural formula shown above] for a period of two weeks. Nandrolone phenylpropionate not only has a direct anabolic effect itself; it also boosts the concentration of IGF-1.
The Taiwanese gave one group of mice a low dose and another group a high dose of nandrolone phenylpropionate. The human equivalent of the doses they used would be about 80 and 800 mg nandrolone phenylpropionate per week.
A control group was given injections containing oil instead.
Results
The mice that had been given steroids died sooner than the mice in the control group, as you can see in the figure below. The higher the dose, the more severe the septic shock.
Conclusions
Source:
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