Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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06.10.2017 |
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Physical exercise may improve lung cancer survival chances
Study
Results
The researchers found more of the suicide enzyme caspase-3 in the mice that exercised. This enzyme is normally activated by the p53 anti-cancer gene. This gene is damaged in about half of the tumours of people with lung cancer, and in many other tumours the gene no longer functions well because of other damage.
The researchers observed a considerably raised level of activity of the p53 gene in all 10 physically active mice.
Mechanism
"In healthy patients, exercise is a known promoter of p53 translocation into the mitochondria in skeletal muscle as well as increased p53 phosphorylation, which is associated with increased protein stability and activity. It is well known that p53 acts as a quintessential tumor suppressor gene by inducing cell-cycle arrest, apoptosis and senescence."
"These results represent novel findings, because increased levels of functional p53 protein were observed in lung tumors from exercising mice. Although A549 lung adenocarcinoma cells do not contain a recognized p53 mutation, our sedentary mouse lung tumors did demonstrate impaired p53 levels, with no measurable p53 protein and a phenotype consistent with a rapidly growing lung tumor. Many p53 wild-type tumors exhibit similar behavior because of increases in negative regulators of p53, such as MDM2."
"Thus, exercise is likely stabilizing wild-type p53 proteins and rendering them more effective at tumor suppression."
Conclusion
"Future research directions include exploratory studies in humans examining the effects of cardiovascular exercise on lung cancer progression."
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