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21.08.2008






New anabolic compound from Johnson & Johnson

When you’re used to the chemical structure of anabolic steroids like testosterone, trenbolone and boldenon, it looks weird, Johnson & Johnson’s new anabolic compound. But according to a recently published article in the Journal of Steroid Biochemistry & Molecular Biology, it works even though it doesn’t have a snappy name yet. The researchers have called it JNJ-37654032 for now.

JNJ-37654032 is not a steroid, but a neo-anabolic: an agent that interacts with the androgen receptor, but doesn’t look at all like the steroid-like androgens for which that receptor is intended. Agents like this are officially called SARMs or Selective Androgen Receptor Modulators.

JNJ-37654032 cannot convert into estradiol or DHT, and therefore it has fewer side effects than testosterone. Researchers look at these kinds of agents hoping to find a muscle strengthener that doesn’t lower women’s voices or give them more body hair, or lead to hypertrophy of the prostate or gyno in men. And this agent doesn’t affect the receptors for progesterone and estradiol either.

Johnson & Johnson, like Bristol-Myers Squibb, Acadia Pharmaceuticals, Karo Bio and of course GTx – the company that invented the first SARMs – has been working for some time already on neo-anabolics.

Last year researchers at Johnson & Johnson published an article on tests with SARM (S)-7c. (S)-7c helped castrated test animals produce more muscle mass, but reduced the prostate in the test animals that were intact. The article did not reveal what (S)-7c did with the muscle mass of the intact test animals. Not much good, probably.

Well, JNJ-37654032 does better. A little better.

Like (S)-7c, JNJ-37654032 reduces the prostate of intact rats, as the figure below shows. This new anabolic agent was administered to the rats through their food. JNJ-37654032 is available in an oral form.

The prostate reduction is most significant at a dose of 0.3 mg per kg body weight per day: the organ loses one-third of its original size.

"JNJ-37654032 could be an effective anabolic agent in men", the researchers conclude. "Unlike most other SARMs, JNJ-37654032 has partial antagonist activity at the prostate that may give it a safety advantage in eugonadal men."

Sounds great, but if you look at this study with ‘ergogenic’ eyes, you will frown upon the figures shown below.

Like (S)-7c, JNJ-37654032 reduces the prostate of intact rats, as the figure below shows. This new anabolic agent was administered to the rats through their food. JNJ-37654032 is orally available.

TP is good old testosterone propionate. The figure shows the effect of daily use of testosterone and JNJ-37654032 on 6-month-old castrated rats, treated for a period of 2.5 months. 2.5 mg per kg body weight per day of the old-fashioned testosterone made the muscle mass grow heavily and the fat mass decrease. 1 mg per kg body weight per day of JNJ-37654032 has less effect on the growth of muscle mass, but makes the fat mass grow.

And the strange thing is….. the researchers don’t mention this.

Johnson & Johnson are testing more neo-anabolic agents, and will no doubt publish outcomes in the future. Maybe we will see more interesting agents in those publications.

Source:
J Steroid Biochem Mol Biol. 2008 Jun; 110(3-5):207-13.