Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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09.08.2010 |
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Ibuprofen helps immune cells build up muscle tissue
Inflammation & exercise
Ibuprofen – in full 2-isobutylphenyl-propanoic-acid – inhibits the production of aggressive compounds by the immune cells. If you add this information to what you know about the role of immune cells in trained muscles, then you’ll automatically wonder what happens if you combine training with ibuprofen.
Study
Rats in the control group were allowed to use their legs and were given salts [AMBU: PBS] or ibuprofen [AMBU: IBU]. The researchers pumped the salts and the ibuprofen directly into the rats' stomachs, using a tube.
The rats in the experimental groups were also given salts [RELOAD: PBS] or ibuprofen. The researchers gave the animals 10 mg ibuprofen per kg bodyweight on 4 different occasions: 8 hours before they regained the use of their hind legs and 8, 16 and 24 afterwards [RELOAD: PRE-IBU]. There was also a group of rats that were not administered ibuprofen on the first occasion [RELOAD: POST-IBU].
Results
ED2+ macrophages are normally found in muscles: they belong there. In earlier publications the same researchers report that the immune cells become more active as muscles recover. [J Appl Physiol. 1994 Jul; 77(1): 290-7.]
A bigger increase in the number of ED2+ macrophages was accompanied by fewer dead muscle cells.
"The increase in ED2+ macrophage concentration and decrease in necrosis may be mechanistically related because ED2+ macrophages have been associated with muscle regeneration and repair", the researchers write.
Conclusion
The researchers received money from a "Cybex research grant awarded by the American College of Sports Medicine" and the space organisation NASA.
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